The Zbrush 3D navigation techniques are optimized for use with a graphics tablet (eg Wacom Intuos – my personal favorite).
>> Press the pen down and drag on the blank canvas to rotate your mesh.
>> Whilst rotating, try holding down Shift key to snap to the nearest orthographic view (top, side, front etc).
>> Hold Alt key down and drag on the blank canvas to pan your mesh.
>> Hold down Alt key, drag on the blank canvas and let go of alt (whilst still dragging) to zoom in and out.
>> Hold down Alt key and tap once on the blank canvas to frame your mesh.
Familiarise yourself with the interface, exploring the various menus.
Read as many tool-tips as you can Ã¢â‚¬â€œ they are extremely useful!
Do be careful with Memory settings.